SYT1

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Protein-coding gene in the species Homo sapiens

title: "SYT1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SYT1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

Function

Synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions (Ca2+) in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. [Supplied by OMIM]

SYT1 is the master switch responsible for allowing the human brain to release neurotransmitters. SYT1 senses calcium ion concentrations as low as 10 ppm and subsequently signals the SNARE complex to open fusion pores.

Interactions

SYT1 has been shown to interact with SNAP-25, STX1A and S100A13.

Clinical Significance

Mutations in the SYT1 gene cause a rare neurodevelopmental disorder known as SYT1-associated neurodevelopmental disorder (or Baker-Gordon Syndrome).

References

References

  1. (Jan 1991). "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans". The Journal of Biological Chemistry.
  2. (March 2001). "Synaptotagmin I functions as a calcium regulator of release probability". Nature.
  3. "Entrez Gene: SYT1 synaptotagmin I".
  4. (Mar 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry.
  5. (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron.
  6. (Jan 1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch". Neuron.
  7. (Jul 1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell.
  8. (Aug 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry.
  9. (Jul 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry.
  10. (2018). "SYT1-associated neurodevelopmental disorder: a case series". Brain.
  11. "OMIM entry: Baker-Gordon Syndrome".

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