Syntaxin 3

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Protein-coding gene in the species Homo sapiens

title: "Syntaxin 3" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/Syntaxin_3" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Syntaxin 3, also known as STX3, is a protein which in humans is encoded by the STX3 gene.

Function

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils. STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid. Mutations in Syntaxin 3 cause Microvillus inclusion disease.

Interactions

Syntaxin 3 has been shown to interact with SNAP-25, SNAP23 and SNAP29.

References

References

  1. (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun..
  2. (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol..
  3. "Entrez Gene: STX3 syntaxin 3".
  4. (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature.
  5. (2014). "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology.
  6. (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem..
  7. (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem..
  8. (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem..
  9. (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol..
  10. (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun..

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