SUMO4

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Protein-coding gene in the species Homo sapiens

title: "SUMO4" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SUMO4" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.

Function

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.

Interactions

SUMO4 has been shown to interact with IκBα.

References

References

  1. (Jun 2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". The Journal of Biological Chemistry.
  2. "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)".
  3. (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics.

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