STX8

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Protein-coding gene in the species Homo sapiens

title: "STX8" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["genes-mutated-in-mice"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/genes-mutated-in-mice" source: "https://en.wikipedia.org/wiki/STX8" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.

Interactions

STX8 has been shown to interact with Vesicle-associated membrane protein 8, VTI1B and STX7.

References

(Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry.
(Apr 1999). "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)". Biochemical and Biophysical Research Communications.
"Entrez Gene: STX8 syntaxin 8".
(Feb 2009). "Interaction between syntaxin 8 and HECTd3, a HECT domain ligase". Cellular and Molecular Neurobiology.
(October 2008). "Syntaxin 8 has two functionally distinct di-leucine-based motifs". Cellular & Molecular Biology Letters.
(Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal.
(Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature.
(Mar 2000). "Preferential association of syntaxin 8 with the early endosome". Journal of Cell Science.

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