Stephania

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Genus of plants

title: "Stephania" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["stephania", "medicinal-plants", "menispermaceae-genera", "dioecious-plants", "caudiciform-plants", "taxa-named-by-joão-de-loureiro"] description: "Genus of plants" topic_path: "general/stephania" source: "https://en.wikipedia.org/wiki/Stephania" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Genus of plants ::

| image = Stephania cephalantha 玉咲葛藤 (天問) 001.jpg | image_caption = Stephania cephalantha | taxon = Stephania | authority = Lour. | synonyms = {{genus list |Byrsa |Noronha |Clypea |Blume |Homocnemia |Miers |Ileocarpus |Miers}} | synonyms_ref =

Stephania is a genus of flowering plants in the family Menispermaceae. It includes 70 species native to tropical and southern Africa, eastern and southern Asia, Australia, and the tropical Pacific Islands. They are herbaceous perennial vines, growing to around four metres tall, with a large tuber. The leaves are arranged spirally on the stem and are peltate, with the leaf petiole attached near the centre of the leaf. The name Stephania comes from the Greek, "a crown". This refers to the anthers being arranged in a crown-like manner.

One species, S. tetrandra, is among the 50 fundamental herbs used in traditional Chinese medicine, where it is called han fang ji (漢防己, "Chinese fang ji"). Other plants named fang ji are sometimes substituted for it. Other varieties substituted include Cocculus thunbergii, C. trulobus, Aristolochia fangchi, Stephania tetrandria, and Sinomenium acutum. Notable among these is guang fang ji (廣防己, "(GuangDong, GuangXi) fang ji", Aristolochia fangchi. Because of its toxicity, it is used in TCM only with great caution.

Species

70 species are accepted. |Stephania andamanica |Diels |Stephania bancroftii |F.M.Bailey |Stephania brachyandra |Diels |Stephania brevipedunculata |C.Y.Wu & D.D.Tao |Stephania brevipes |Craib |Stephania cambodica |Gagnep. |Stephania capitata |(Blume) Spreng. |Stephania cephalantha |Hayata |Stephania chingtungensis |H.S.Lo |Stephania corymbosa |(Blume) Walp. |Stephania crebra |Forman |Stephania cyanantha |Welw. ex Hiern |Stephania delavayi |Diels |Stephania dentifolia |H.S.Lo & M.Yang |Stephania dicentrinifera |H.S.Lo & M.Yang |Stephania dictyoneura |Diels |Stephania dielsiana |Y.C.Wu |Stephania dinklagei |(Engl.) Diels |Stephania dolichopoda |Diels |Stephania ebracteata |S.Y.Zhao & H.S.Lo |Stephania elegans |Hook.f. & Thomson |Stephania epigaea |H.S.Lo |Stephania excentrica |H.S.Lo |Stephania formanii |Kundu & S.Guha |Stephania glandulifera |Miers |Stephania gracilenta |Miers |Stephania grandiflora |Forman |Stephania hainanensis |H.S.Lo & Y.Tsoong |Stephania herbacea |Gagnep. |Stephania intermedia |H.S.Lo |Stephania japonica |(Thunb.) Miers |Stephania kaweesakii |Jenjitt. & Ruchis. |Stephania kuinanensis |H.S.Lo & M.Yang |Stephania kwangsiensis |H.S.Lo |Stephania lincangensis |H.S.Lo & M.Yang |Stephania longa |Lour. |Stephania longipes |H.S.Lo |Stephania macrantha |H.S.Lo & M.Yang |Stephania mashanica |H.S.Lo & B.N.Chang |Stephania merrillii |Diels |Stephania micrantha |H.S.Lo & M.Yang |Stephania mildbraedii |Diels |Stephania miyiensis |S.Y.Zhao & H.S.Lo |Stephania moluccana |Forman |Stephania montana |Diels |Stephania neoguineensis |Kundu & S.Guha |Stephania novenanthera |Heng C.Wang |Stephania oblata |Craib |Stephania officinarum |H.S.Lo & M.Yang |Stephania papillosa |Craib |Stephania pierrei |Diels |Stephania polygona |N.H.Xia & V.T.Chinh |Stephania psilophylla |(C.Presl) Forman |Stephania renifolia |Forman |Stephania reticulata |Forman |Stephania rotunda |Lour. |Stephania salomonum |Diels |Stephania sinica |Diels |Stephania suberosa |Forman |Stephania subpeltata |H.S.Lo |Stephania succifera |H.S.Lo & Y.Tsoong |Stephania sutchuenensis |H.S.Lo |Stephania tomentella |Forman |Stephania tuberosa |Forman |Stephania venosa |(Blume) Spreng. |Stephania viridiflavens |H.S.Lo & M.Yang |Stephania wightii |(Arn. ex Wight) Dunn |Stephania yunnanensis |H.S.Lo |Stephania zippeliana |Miq.}} ;Fossil species

;Formerly placed here

Toxicity

::figure[src="https://upload.wikimedia.org/wikipedia/commons/6/67/Stephania-delavayi_Menispermaceae_flowers.jpg" caption="Female flowers of ''[[Stephania delavayi]]''"] ::

There is evidence that a few species of Stephania are toxic. However, the most commonly available species in the United States, Stephania tetrandra, has not been shown to be toxic. Any confusion regarding the possible toxicity of Stephania tetrandra was entirely due to an inadvertent shipment of Aristolochia fangchi sent in its stead to a Belgian clinic in 1993. The errant batch of Aristolochia was later confirmed via phytochemical analysis.

Chemistry

Chemical investigation of Stephania rotunda Lour. growing in Vietnam in 2005 led to the isolation and structural elucidation of three new alkaloids, 5-hydroxy-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one, thaicanine 4-O-beta-D-glucoside, as well as (−)-thaicanine N-oxide (4-hydroxycorynoxidine), along with 23 known alkaloids.

References

References

  1. . (n.d.). ["Stephania Lour."](https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:27017-1). *The Trustees of the Royal Botanic Gardens, Kew*.
  2. . (n.d.). ["Stephania Lour."](https://www.catalogueoflife.org/data/taxon/645YR). *Species 2000*.
  3. Les Robinson. (2003). "Field Guide to the Native Plants of Sydney". Kangaroo Press.
  4. (1988). "A Synopsis of Thai Menispermaceae". Royal Botanic Gardens, Kew.
  5. GRIN. "GRIN Species Records of genus ''Stephania''". [[United States Department of Agriculture.
  6. "''Botryodiscia tetrandra'' (S.Moore) L.Lian & Wei Wang". [[Royal Botanic Gardens, Kew]].
  7. [http://ugcdskpdf.unipune.ac.in/Journal/uploads/CH/CH100008-A-3.pdf] Journal of Ethnopharmacology 132 (2010). p. 380
  8. Nunez, Kelvin R.. (2006). "Trends in Kidney Cancer Research". Nova Science Publishers.
  9. (September 2005). "Isoquinolone and protoberberine alkaloids from Stephania rotunda". Die Pharmazie.

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