SPR domain
title: "SPR domain" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["spr-domain", "protein-domains"] topic_path: "general/spr-domain" source: "https://en.wikipedia.org/wiki/SPR_domain" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox protein family"]
| Field | Value |
|---|---|
| Symbol | SPR |
| Name | Sprouty |
| Pfam | PF05210 |
| InterPro | IPR007875 |
| :: |
| Symbol = SPR | Name = Sprouty | image = | width = | caption = | Pfam = PF05210 | Pfam_clan = | InterPro = IPR007875 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = In molecular biology the SPR domain is a protein domain found in the Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.
The SPR domain can occur in association with the WH1 domain (see ) (located in the N-terminus) in the Spred proteins.
Examples
Human genes encoding protein containing the SPR domain include:
References
References
- (December 2001). "Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis". Mechanisms of Development.
- (November 2002). "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes". Molecular and Cellular Biology.
- (June 2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". The Biochemical Journal.
- (October 2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". The Journal of Biological Chemistry.
- (August 2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature.
- (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology.
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