SOCS3

Quality 0.50 · 1 view · Updated 2 months ago

Protein

title: "SOCS3" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SOCS3" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein ::

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

SOCS3 is a conserved gene, found in across the animal kingdom, including Drosophila, chickens, and crocodiles.

Function

The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.

For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3.

Overexpression of SOCS3 inhibits insulin signaling in adipose tissue and the liver, but not in muscle. But deletion of SOCS3 in the skeletal muscle of mice protects against obesity-related insulin resistance.

SOCS3 contributes to both leptin resistance and insulin resistance as a result of increased ceramide synthesis. For that reason, studies have shown that removal of the SOCS gene prevents against insulin resistance in obesity

Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase.

Interactions

SOCS3 has been shown to interact with:

Regulation

There is some evidence that the expression of SOCS3 is regulated by the microRNA miR-203, miR-409-3p and miR-1896.

References

References

  1. (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun.
  2. (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun.
  3. (2013). "Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms". Molecular Biology of the Cell.
  4. (2019). "Evolutionary view of pluripotency seen from early development of non-mammalian amniotes". Developmental Biology.
  5. (2021). "Genomic evidence of adaptive evolution in the reptilian SOCS gene family". PeerJ.
  6. (2013). "Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity". [[Diabetes (journal).
  7. (2009). "Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome". [[American Journal of Physiology]].
  8. "Entrez Gene: SOCS3 suppressor of cytokine signaling 3".
  9. (September 2000). "CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2". J. Biol. Chem..
  10. (May 2002). "A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor". Eur. J. Biochem..
  11. (November 2000). "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun..
  12. (June 1999). "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells.
  13. (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130". J. Biol. Chem..
  14. (May 2001). "Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras". Nat. Cell Biol..
  15. (2008). "miR-203 represses 'stemness' by repressing DeltaNp63.". Cell Death Differ.
  16. (2010). "The expression of microRNA-203 during human skin morphogenesis.". Exp Dermatol.
  17. (January 2019). "MiR-409-3p and MiR-1896 co-operatively participate in IL-17-induced inflammatory cytokine production in astrocytes and pathogenesis of EAE mice via targeting SOCS3/STAT3 signaling". Glia.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::