SNW1
Protein-coding gene in the species Homo sapiens
title: "SNW1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SNW1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein-coding gene in the species Homo sapiens ::
SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.
Function
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Interactions
SNW1 has been shown to interact with:
- CIR,
- Calcitriol receptor,
- Histone deacetylase 2,
- Mothers against decapentaplegic homolog 2,
- Mothers against decapentaplegic homolog 3,
- NOTCH1
- Nuclear receptor co-repressor 2,
- Nuclear receptor coactivator 1,
- PABPN1,
- RBPJ,
- Retinoblastoma protein, and
- SKI protein.
References
References
- (Nov 1996). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene.
- (Jun 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". The Journal of Biological Chemistry.
- "Entrez Gene: SNW1 SNW domain containing 1".
- (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology.
- (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development.
- (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". The Journal of Biological Chemistry.
- (May 2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Human Molecular Genetics.
- (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology.
- (Dec 2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Research.
- (Sep 2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Research.
- (Mar 1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene.
- (May 2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". The Journal of Biological Chemistry.
::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::