SND1

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Protein and coding gene in humans

title: "SND1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein and coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SND1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein and coding gene in humans ::

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. SND1 is a main component of RISC complex and plays an important role in miRNA function. SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. SND1 is also involved in Autism.

Clinical significance

SND1 acts as oncogene in many cancers and in hepatocellular carcinoma progression. SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221. SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling. SND1 expression is regulated by Mir-184 in gliomas.

Interactions

SND1 has been shown to interact with MYB,

SND1 also interacts with G3BP (stress granule protein) and AEG-1.

References

References

  1. (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology.
  2. (Jan 1997). "The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development". The Biochemical Journal.
  3. (Sep 2003). "Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5". Molecular Endocrinology.
  4. "Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1".
  5. (Oct 2007). "SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis". Cancer Research.
  6. (May 2011). "Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma". Hepatology.
  7. (Apr 2011). "Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology". Pharmacology & Therapeutics.
  8. Ying, Muying. (1 January 2012). "Tudor domain-containing proteins of Drosophila melanogaster". Development, Growth & Differentiation.
  9. (Sep 2010). "Linkage and candidate gene studies of autism spectrum disorders in European populations". European Journal of Human Genetics.
  10. (Nov 2010). "MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis". Mutation Research.
  11. (Jun 2009). "Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer". The American Journal of Pathology.
  12. (Feb 2009). "Novel breast cancer metastasis-associated proteins". Journal of Proteome Research.
  13. (Apr 2012). "Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221". The Journal of Biological Chemistry.
  14. (2014). "Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling". FEBS Open Bio.
  15. (Mar 2015). "Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness". Neuro-Oncology.
  16. (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development.
  17. (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell.
  18. (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology.
  19. (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America.
  20. (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal.
  21. (Aug 2010). "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions". FEBS Letters.

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