Simeticone

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Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas

title: "Simeticone" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["antiflatulents", "food-additives", "silicon", "silicon-dioxide", "digestive-system", "silicones", "over-the-counter-drugs-in-the-united-states"] description: "Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas" topic_path: "geography/united-states" source: "https://en.wikipedia.org/wiki/Simeticone" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas ::

::data[format=table title="Infobox drug"]

Field	Value
Verifiedfields	changed
verifiedrevid	417768970
IUPAC_name	Poly(dimethylsiloxane), silicon dioxide
image	Simethicone structure.svg
	image_class
tradename	Infacol, Wind-eze, WindSetlers, others
USAN	Simethicone
Drugs.com
pregnancy_category	C
legal_US	OTC
routes_of_administration	Oral
	bioavailability
protein_bound	0%
metabolism	Not metabolized
elimination_half-life	N/A
excretion	Feces
	CAS_number_Ref
CAS_number	8050-81-5
ATC_prefix	A03
ATC_suffix	AX13
PubChem	6433516
ChemSpiderID_Ref
ChemSpiderID	None
DrugBank_Ref
DrugBank	DB09512
ChEMBL_Ref
ChEMBL	1200838
	chemical_formula
molecular_weight	Variable
::

Medical uses

::figure[src="https://upload.wikimedia.org/wikipedia/commons/9/90/Simethiconetablets.jpg" caption="Simethicone tablets"] ::

Simethicone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence. While there is a lack of conclusive evidence that simethicone is effective for this use,⁣ studies have shown that it can relieve symptoms of functional dyspepsia and functional bloating.

It has not been fully established that simethicone is useful to treat colic in babies, and it is not recommended for this purpose. A study in the United Kingdom reported that according to parental perception simethicone helped infant colic in some cases.

Simethicone can also be used for suspected postoperative abdominal discomfort in infants.

Side effects

Simethicone does not have any serious side effects. Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.

Though poorly documented, some studies show a possible negative interaction between simethicone and levothyroxine, meaning it can possibly bind levothyroxine in the GI tract and hence reduce its absorption leaving the patient prone to clinical manifestations of hypothyroidism. It is important to mention the long T1/2 of levothyroxine which makes the phenomenon a matter of at least a week of using levothyroxine with simethicone. To prevent this interaction, simethicone is recommended to be taken at least 4 hours before or after levothyroxine.

Pharmacology

Simethicone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract. This allows gas bubbles to leave the GI tract as flatulence or belching. Simethicone does not reduce or prevent the formation of gas. Its effectiveness has been shown in several in vitro studies.

Chemistry

Simethicone is a mixture of dimethicone and silicon dioxide.

Names

The INN name is "simethicone", which was added to the INN recommended list in 1999.

Simethicone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.

Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Polysilane Junior, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.

It is also marketed as a combination drug:

with algeldrate as Kestomatine
with aluminium or magnesium salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Magasida, Mi-Acid, Mygel, Mylagen, Mylanta, Polysilane, Polysilane Delalande, Rumibex and Trial AG
with alverine as Avarin, Meteospasmyl, Nady-Spasmyl
with barium sulfate as Bario Dif
with bismuth as Gastop
with calcium carbonate as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
with activated charcoal as Carbosylane, Clingest, Finigax. Flatuna
with cinitapride as Rogastril Plus
with clebopride as Flatoril
with dicycloverine as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
with domperidone as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
with hydrotalcite as Altacide and Talsil Forte
with homatropine as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
with lactulose as Dinolak
with levonorgestrel as Jaydess
with loperamide as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
with magaldrate as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
with metoclopramide as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
with mosapride as M-Pride-MPS, Moxar, Moza MPS
with pancreatin as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
with papaverine as Espasmo Siligas
with pinaverium as Alevian Duo, Pladuet, Planex
with pipenzolate bromide as Cadinol, Gasorbol Gotas
with phloroglucinol as Meteoxane
with trimebutine as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
with urea as Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.

References

"Simethicone names". Drugs.com.
(April 2016). "Simethicone tablet". NIH DailyMed.
(10 October 2019). "Simeticone". [[NHS]].
(July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology.
"Simethicone". [[drugs.com]].
(September 2002). "A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". Wiley.
(25 September 2018). "Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study". AME Publications.
(September 2016). "Pain-relieving agents for infantile colic". The Cochrane Database of Systematic Reviews.
(March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing.
(March 1998). "Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants". Journal of Clinical Anesthesia.
"Simethicone Side Effects in Detail". Drugs.com.
(February 2017). "Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review". Clinical Therapeutics.
(September 2011). "Drug interaction of levothyroxine with infant colic drops". Archives of Disease in Childhood.
(January 2021). "StatPearls [Internet].". StatPearls Publishing.
(4 September 2015). "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders.
(May 1994). "Mechanism of antifoaming action of simethicone". Wiley.
(12 May 2010). "Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro". Krause & Pachernegg.
(2006). "Dimethicone". Merck.
(1999). "Recommended INN List 42". WHO Drug Information.
"Simeticone international brands". Drugs.com.

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