SH2B1

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Protein-coding gene in the species Homo sapiens

title: "SH2B1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SH2B1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.

Interactions

SH2B1 has been shown to interact with:

Clinical significance

Variations close to or in the SH2B1 gene have been found to associate with obesity in two very large genome wide association studies of body mass index (BMI). Furthermore, SH2B1 deletions are associated with severe early-onset obesity.

References

References

  1. (Apr 2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J Biol Chem.
  2. (Jan 2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain". Mamm Genome.
  3. "Entrez Gene: SH2B1 SH2B adaptor protein 1".
  4. (November 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron.
  5. (October 1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase". Biochem. J..
  6. (November 1997). "Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling". Mol. Cell. Biol..
  7. (October 2002). "Jak2 is involved in c-Myc induction by Bcr-Abl". Oncogene.
  8. (March 2000). "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop". FEBS Lett..
  9. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet..
  10. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.". Nat. Genet..
  11. (February 2010). "Large, rare chromosomal deletions associated with severe early-onset obesity". Nature.

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