Sequon

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title: "Sequon" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["peptide-sequences", "glycoproteins"] description: "Sequence of consecutive amino acids in a protein" topic_path: "general/peptide-sequences" source: "https://en.wikipedia.org/wiki/Sequon" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Sequence of consecutive amino acids in a protein ::

A sequon is a sequence of consecutive amino acids in a protein that can serve as the attachment site to a polysaccharide, frequently an N-linked-Glycan.{{cite journal|title=Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts |year=2011|doi=10.1073/pnas.1105880108|doi-access=free|last1=Price|first1=J. L.|last2=Powers|first2=D. L.|last3=Powers|first3=E. T.|last4=Kelly|first4=J. W.|journal=Proceedings of the National Academy of Sciences|volume=108|issue=34|pages=14127–14132|pmid=21825145|pmc=3161607|bibcode=2011PNAS..10814127P}} The polysaccharide is linked to the protein via the nitrogen atom in the side chain of asparagine (Asn). The sequon for N-glycosylation is either Asn-X-Ser or Asn-X-Thr, where X is any amino acid except proline, Ser denoting serine and Thr threonine. Occasionally, other amino acids can take the place of Ser and Thr, such as in the leukocyte surface protein (CD69), where the amino acid sequence Asn-X-Cys is an acceptable sequon for the addition of N-linked glycans.{{cite book |last= Brooks |first= Susan |author2=Miriam Dwek |author3=Udo Schumacher |title= Functional and molecular glycobiology. |year= 2002 |publisher= BIOS Scientific |location= Oxford UK |isbn= 1-85996-022-7

References

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