Sel-12

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title: "Sel-12" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["transmembrane-proteins", "caenorhabditis-elegans-genes"] topic_path: "general/transmembrane-proteins" source: "https://en.wikipedia.org/wiki/Sel-12" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. sel-12 positively regulates the lin-12 and glp-1 Notch signaling pathways during hermaphrodite gonadal, vulval, and germline development. sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).

C. elegans gene abbreviations: sel, Suppressor/Enhancer of Lin-12; lin, cell LINeage defective; glp, Germ Line Proliferation defective.

References

References

  1. Diane Levitan, Iva Greenwald. (September 1995). "Facilitation of ''lin-12''-mediated signalling by ''sel-12'', a ''Caenorhabditis elegans'' ''S182'' Alzheimer's disease gene". Nature.
  2. Stefan Eimer. (2003). "Analysis and suppression of mutant ''sel-12'' in ''C. elegans''". Ph.D. Thesis, Ludwig-Maximilians Universität, Munich, Germany.

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