SCN4B

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Protein-coding gene in the species Homo sapiens

title: "SCN4B" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["sodium-channels"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/sodium-channels" source: "https://en.wikipedia.org/wiki/SCN4B" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein is encoded by the SCN4B gene. Mutations in the SCN4B are associated with long QT syndrome.

SCN4B might additionally function as a cell adhesion molecule.

References

References

  1. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology.
  2. "Entrez Gene: sodium channel".
  3. (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation.
  4. (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports.
  5. (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.". J Biol Chem.

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sodium-channels