SAP130
Protein-coding gene in humans
title: "SAP130" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/SAP130" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein-coding gene in humans ::
Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.
Function
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]
Interactions
SAP130 has been shown to interact with:
- CSN1S1,
- CUL2,
- Myc,
- SIN3A, and
- Von Hippel–Lindau tumor suppressor and
References
References
- (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research.
- (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology.
- "Entrez Gene: SAP130 Sin3A-associated protein, 130kDa".
- (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochemistry.
- (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry.
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