Salicylamide

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Chemical compound

title: "Salicylamide" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["analgesics", "antipyretics", "salicylamides"] description: "Chemical compound" topic_path: "general/analgesics" source: "https://en.wikipedia.org/wiki/Salicylamide" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Watchedfields = changed | verifiedrevid = 464386263 | IUPAC_name = 2-Hydroxybenzamide | image = Salicylamide.svg | image_class = skin-invert-image | width = 150 | image2 = Salicylamide-3D-balls.png | image_class2 = bg-transparent | tradename = | MedlinePlus = a681004 | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = Renal | CAS_number_Ref = | CAS_number = 65-45-2 | ATC_prefix = N02 | ATC_suffix = BA05 | ATC_supplemental = (combinations) | PubChem = 5147 | DrugBank_Ref = | DrugBank = DB08797 | ChemSpiderID_Ref = | ChemSpiderID = 4963 | UNII_Ref = | UNII = EM8BM710ZC | ChEBI_Ref = | ChEBI = 32114 | ChEMBL_Ref = | ChEMBL = 27577 | NIAID_ChemDB = 018403 | C=7 | H=7 | N=1 | O=2 | smiles = O=C(c1ccccc1O)N | StdInChI_Ref = | StdInChI = 1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) | StdInChIKey_Ref = | StdInChIKey = SKZKKFZAGNVIMN-UHFFFAOYSA-N | density = 1.33 | solubility = Soluble in hot water, ether, alcohol, and chloroform.

Salicylamide (o-hydroxybenzamide or amide of salicyl) is a non-prescription drug with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin. Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedy PainAid. It was also an ingredient in the over-the-counter pain remedy BC Powder but was removed from the formulation in 2009, and Excedrin used the ingredient from 1960 to 1980 in conjunction with aspirin, acetaminophen, and caffeine. It was used in later formulations of Vincent's powders in Australia as a substitute for phenacetin.

::figure[src="https://upload.wikimedia.org/wikipedia/commons/7/7c/Salicylamide_substance_photo.jpg" caption="Pure salicylamide is a white or slightly pink crystalline powder"] ::

Derivatives

Derivatives of salicylamide include ethenzamide, labetalol, medroxalol, otilonium, oxyclozanide, salicylanilide, niclosamide, and raclopride.

References

References

  1. (2008). "Foye's Principles of Medicinal Chemistry". Lippincott Williams & Wilkins.
  2. "Salicylamide". Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam-Webster, Inc..

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analgesicsantipyreticssalicylamides