RBBP8

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Protein-coding gene in the species Homo sapiens

title: "RBBP8" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/RBBP8" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

DNA repair

RBBP8 is involved in the DNA repair process of homologous recombination. It was proposed that, in gastric cancer cells, inhibition of RBBP8 expression could cause a synthetic lethal effect along with PARP inhibitor treatment.

Interactions

RBBP8 has been shown to interact with:

References

References

  1. (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics.
  2. (November 2007). "Human CtIP promotes DNA end resection". Nature.
  3. "Entrez Gene: RBBP8 retinoblastoma binding protein 8".
  4. (September 2023). "Mechanism of RBBP8-mediated homologous recombination repair in gastric cancer synthetic lethal". Chronic Dis Transl Med.
  5. (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature.
  6. (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem..
  7. (Dec 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem..
  8. (November 1998). "Characterization of a carboxy-terminal BRCA1 interacting protein". Oncogene.
  9. (November 2001). "Effect of DNA damage on a BRCA1 complex". Nature.
  10. (September 1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem..
  11. (June 2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem..
  12. (April 1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem..
  13. (April 1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem..
  14. (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem..
  15. (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer.
  16. (May 2000). "Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins". Mol. Cell. Biol..
  17. (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A..
  18. (Dec 2003). "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway". Oncogene.

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