RAB11A

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Protein-coding gene in the species Homo sapiens

title: "RAB11A" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/RAB11A" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

Function

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.

Rab-11a controls intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signaling

Interactions

RAB11A has been shown to interact with:

References

References

  1. (January 1991). "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3". Oncogene.
  2. (June 1998). "Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins". FEBS Letters.
  3. "Entrez Gene: RAB11A RAB11A, member RAS oncogene family".
  4. (October 2010). "The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes". Immunity.
  5. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology.
  6. (April 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry.
  7. (July 2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain". The Journal of Biological Chemistry.
  8. (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry.
  9. (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". The Journal of Biological Chemistry.
  10. (December 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochemical and Biophysical Research Communications.
  11. (March 2013). "Rab11 regulates cell–cell communication during collective cell movements". Nature Cell Biology.

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