QMPSB

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CA: Schedule II
DE: NpSG (Industrial and scientific use only)
UK: Under Psychoactive Substances Act
IUPAC name
8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate
312606-87-4
3929482
3151524
55Q8B94HS5
ChEMBL245876
DTXSID901045939
C22H22N2O4S
410.49 g·mol−1
Interactive image
SMILES
Cc1ccc(cc1S(=O)N2CCCCC2)C(=O)Oc3cccc4cccnc34
InChI
InChI=1S/C22H22N2O4S/c1-16-10-11-18(15-20(16)29(26,27)24-13-3-2-4-14-24)22(25)28-19-9-5-7-17-8-6-12-23-21(17)19/h5-12,15H,2-4,13-14H2,1H3Key:WORIMYADZQJWOU-UHFFFAOYSA-N

QMPSB is an arylsulfonamide-based synthetic cannabinoid that has been sold as a designer drug.

QMPSB was first discovered by Nathalie Lambeng and colleagues in 2007. It acts as a full agonist of the CB1 receptor and CB2 receptor with Ki values of 3 nM and 4 nM, respectively. Many related derivatives were subsequently produced, with the main focus of this work being to increase selectivity for the non-psychoactive CB2 receptor. This work led on from an earlier series of sulfamoyl benzamide derivatives for which a patent was filed in 2004.

The quinolin-8-yl ester motif of QMPSB led to the discovery of other designer cannabinoids such as PB-22 and BB-22.

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