PROX1

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title: "PROX1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["transcription-factors"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "arts/film" source: "https://en.wikipedia.org/wiki/PROX1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.

Interactions

PROX1 has been shown to interact with EP300.

Production

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

PROX1 is used as a marker for lymphatic endothelium in biopsy samples. It has also been identified as an inhibitor of Müller glia (MG)-mediated retinal regeneration in mice that, when blocked from accessing MG cells, allowed retinal regeneration to occur, suggesting a possible therapeutic research pathway for drugs to treat degenerative diseases (such as retinitis pigmentosa) that lead to vision loss.

Homologous gene

PROX2

References

References

1. (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics.
2. "Entrez Gene: PROX1 prospero-related homeobox 1".
3. (October 2005). "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity". Nature Genetics.
4. Chen, Qin. (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem..
5. (2025-03-25). "Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer". Nature Communications.

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