PROSITE
Database of protein domains, families and functional sites
title: "PROSITE" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["protein-databases", "proteomics"] description: "Database of protein domains, families and functional sites" topic_path: "technology/databases" source: "https://en.wikipedia.org/wiki/PROSITE" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Database of protein domains, families and functional sites ::
::data[format=table title="infobox biodatabase"]
| Field | Value |
|---|---|
| title | PROSITE |
| logo | [[Image:Prosite.png]] |
| description | PROSITE, a protein domain database for functional characterization and annotation. |
| center | Swiss Institute of Bioinformatics |
| laboratory | Structural Biology and Bioinformatics Department |
| pmid | 19858104 |
| released | |
| url | |
| :: |
|title = PROSITE |logo = [[Image:Prosite.png]] |description = PROSITE, a protein domain database for functional characterization and annotation. |scope = |organism = |center = Swiss Institute of Bioinformatics |laboratory = Structural Biology and Bioinformatics Department |author = |pmid = 19858104 |released = |standard = |format = |url = |download = |webservice = |sql = |sparql = |webapp = |standalone = |license = |versioning = |frequency = |curation = PROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch, who directed the group for more than 20 years. Since July 2018, the director of PROSITE and Swiss-Prot is Alan Bridge.
PROSITE's uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. Properties from well-studied genes can be propagated to biologically related organisms, and for different or poorly known genes biochemical functions can be predicted from similarities. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif, PROSITE patterns). It is part of the ExPASy proteomics analysis servers.
The database ProRule builds on the domain descriptions of PROSITE. It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
Statistics
, release 2022_01 has 1,902 documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 ProRules.
References
References
- (2006). "ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins". Nucleic Acids Res..
- (2007). "The 20 years of PROSITE". Nucleic Acids Res..
- (2005). "ProRule: a new database containing functional and structural information on PROSITE profiles". Bioinformatics.
::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::