Proflavine

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Column 1	Column 2
Preferred IUPAC name
Acridine-3,6-diamine
CAS Number	.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}92-62-6 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:8452 Y
ChEMBL	ChEMBL55400 Y
ChemSpider	6832 Y
DrugBank	DB01123 Y
ECHA InfoCard	100.001.976
KEGG	C11181 Y
PubChem CID	7099
UNII	CY3RNB3K4T Y
CompTox Dashboard (EPA)	DTXSID9043776
InChI
InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 YKey: WDVSHHCDHLJJJR-UHFFFAOYSA-N YInChI=1/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2Key: WDVSHHCDHLJJJR-UHFFFAOYAC
SMILES
n1c3c(cc2c1cc(N)cc2)ccc(c3)N
Chemical formula	C13H11N3
Molar mass	209.252 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)

Infobox references | |

Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.

Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions. In the presence of light, proflavine can induce double-stranded breaks in DNA.

Proflavine is a fluorescent dye that is sometimes used in microscopic in-vivo imaging due to its intercalation properties. However, there was concern that women exposed to proflavin could develop cervical cancer since they have mutagenesis potential. However, the retrospective analysis performed by Pantano et. al. demonstrated that there is no increased cervical cancer risk after exposure to proflavine.

In astronomical spectroscopy proflavine present in interstellar clouds (derived from the modification in meteorites of polycyclic aromatic hydrocarbons by heteroatoms) strongly absorbs in the blue region at 445 nm. This makes difficult the recording of the spectra of stars that lie behind the clouds.

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