PON3

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Protein-coding gene in the species Homo sapiens

title: "PON3" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/PON3" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.

Function

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.

References

References

  1. (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics.
  2. "Entrez Gene: PON3 paraoxonase 3".

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