PIN domain
title: "PIN domain" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["protein-domains"] topic_path: "general/protein-domains" source: "https://en.wikipedia.org/wiki/PIN_domain" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox protein family"]
| Field | Value |
|---|---|
| Symbol | PIN |
| Name | PIN domain |
| image | PDB_1o4w_EBI.jpg |
| width | 250 |
| caption | Crystal structure of PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Angstrom resolution. |
| Pfam | PF01850 |
| InterPro | IPR002716 |
| SMART | CBS |
| SCOP | 3dbo |
| CDD | cd09852 |
| PDB | , , |
| :: |
| Symbol = PIN | Name = PIN domain | image = PDB_1o4w_EBI.jpg | width = 250 | caption = Crystal structure of PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Angstrom resolution. | Pfam = PF01850 | InterPro = IPR002716 | SMART = CBS | PROSITE = | SCOP = 3dbo | TCDB = | OPM family = | OPM protein = | CDD = cd09852 | PDB = , ,
In molecular biology the PIN domain is a protein domain that is about 130 amino acids in length. PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence- or structure-dependent manner.
PIN domains contain four nearly invariant acidic residues. Crystal structures show these residues clustered together in the putative active site. In eukaryotes PIN domains are found in proteins involved in nonsense mediated mRNA decay, in proteins such as SMG5 and SMG6, and in processing of 18S ribosomal RNA. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operons. These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress.
References
References
- (January 2011). "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array". Protein Engineering, Design & Selection.
- (July 2017). "Comprehensive classification of the PIN domain-like superfamily". Nucleic Acids Research.
- (May 2005). "Prokaryotic toxin-antitoxin stress response loci". Nature Reviews. Microbiology.
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