Peptaibol
Family of transport proteins
title: "Peptaibol" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["antibiotics", "trichoderma", "antimicrobial-peptides"] description: "Family of transport proteins" topic_path: "general/antibiotics" source: "https://en.wikipedia.org/wiki/Peptaibol" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Family of transport proteins ::
::data[format=table title="Infobox protein family"]
| Field | Value |
|---|---|
| Symbol | N/A |
| TCDB | 1.D.5 |
| OPM family | 44 |
| OPM protein | 1ob7 |
| :: |
| Symbol = N/A | Name = | image = | width = | caption = | Pfam = | Pfam_clan = | InterPro = | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = 1.D.5 | OPM family = 44 | OPM protein = 1ob7 | CAZy = | CDD =
Peptaibols are biologically active peptides containing between seven and twenty amino acid residues, some of which are non-proteinogenic amino acids. In particular, they contain α-aminoisobutyric acid along with other unusual aminoacids such as ethylnorvaline, isovaline and hydroxyproline; the N-terminus is acetylated, and the C-terminal amino acid is hydroxylated to an acid alcohol. They are named pebtaibols due to them being peptides containing α-aminoisobutyric acid (Aib) and ending in an alcohol. They are produced by certain fungi, mainly in the genus Trichoderma, as secondary metabolites which function as antibiotics and antifungal agents. Some are referred to as trichorzianines. They are amphipathic which allows them to form voltage-dependent ion channels in cell membranes which create holes in the membrane making them leaky and leading to the death of the cells. As of 2001, over 317 peptaibols had been identified. The most widely known peptaibol is alamethicin.
References
References
- (August 2001). "Peptaibols: models for ion channels". Biochemical Society Transactions.
- (2007). "Profiling of trichorzianines in culture samples of Trichoderma atroviride by liquid chromatography/tandem mass spectrometry". Rapid Communications in Mass Spectrometry.
- (December 1994). "Parallel Formation and Synergism of Hydrolytic Enzymes and Peptaibol Antibiotics, Molecular Mechanisms Involved in the Antagonistic Action of Trichoderma harzianum against Phytopathogenic Fungi". Applied and Environmental Microbiology.
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