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Papain-like protease

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Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large family of cysteine protease enzymes that share structural and enzymatic properties with the group's namesake member, papain. They are found in all domains of life. In animals, the group is commonly referred to as cysteine cathepsins or, in older literature, lysosomal peptidases. In the MEROPS protease enzyme classification system, papain-like proteases belong to Clan CA. These proteases share a common catalytic dyad active site featuring a cysteine amino acid residue that functions as a nucleophile.