ORC2
Protein-coding gene in the species Homo sapiens
title: "ORC2" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/ORC2" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein-coding gene in the species Homo sapiens ::
| Symbol = ORC2 | Name = Origin recognition complex subunit 2 | image = | width = | caption = | Pfam = PF04084 | Pfam_clan = | InterPro = IPR007220 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
Interactions
ORC2 has been shown to interact with:
- CDC6,
- DBF4,
- MCM10,
- MCM2
- MCM4,
- MCM5,
- MCM6,
- MCM7,
- ORC1,
- ORC3,
- ORC4,
- ORC5,
- ORC6, and
- Replication protein A1.
References
References
- (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics.
- "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)".
- (November 2000). "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol..
- (December 2000). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res..
- (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol..
- (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem..
- (July 2001). "Assembly of the human origin recognition complex". J. Biol. Chem..
- (March 2002). "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Mol. Cell.
- (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron.
- (November 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem..
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