O-1918

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Chemical compound

title: "O-1918" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["cannabinoids", "cyclohexenes"] description: "Chemical compound" topic_path: "general/cannabinoids" source: "https://en.wikipedia.org/wiki/O-1918" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| IUPAC_name = 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene | image = O-1918_structure.png | image_class = skin-invert-image | width = 220 | tradename = | CAS_number_Ref = | CAS_number = 536697-79-7 | UNII_Ref = | UNII = 2DGR9Z5BT3 | PubChem = 40469923 | C=19 | H=26 | O=2 | smiles = CC1=CC@@HC@HCC1

O-1918 is a synthetic compound related to cannabidiol, which is an antagonist at two former orphan receptors GPR18 and GPR55, that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB1, non-CB2 mediated effects that have become evident in the course of cannabinoid research.

Subsequent research by using electrophysiological approach has shown that O-1918 is a potent BKCa channel inhibitor.

References

References

  1. (March 2003). "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular Pharmacology.
  2. (June 2010). "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats". British Journal of Pharmacology.
  3. (August 2011). "The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55". Neuroscience Letters.
  4. (October 2011). "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure". Journal of Ocular Pharmacology and Therapeutics.
  5. (June 2013). "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology.
  6. (January 2009). "The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels". The Journal of Pharmacology and Experimental Therapeutics.
  7. (March 2018). "The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells". Vascular Pharmacology.
  8. (June 2017). "Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor". European Journal of Pharmacology.

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cannabinoidscyclohexenes