NSFL1C

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Protein-coding gene in the species Homo sapiens

title: "NSFL1C" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/NSFL1C" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.

Interactions

NSFL1C has been shown to interact with Valosin-containing protein.

References

References

  1. (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res.
  2. "Entrez Gene: NSFL1C NSFL1 (p97) cofactor (p47)".
  3. Uchiyama, Keiji. (Jun 2003). "The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle". J. Cell Biol..

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