Nifurzide

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Column 1
International Drug Names
.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}A07AX04 (WHO)
IUPAC name
5-Nitro-N′-[(1E,2E)-3-(5-nitro-2-furyl)-2-propen-1-ylidene]-2-thiophenecarbohydrazide
39978-42-2 Y
9571044
7845510
Z35R6K4C26
D07251 Y
100.049.735
C12H8N4O6S
336.28 g·mol−1
Interactive image
SMILES
[O-]N+c1ccc(o1)/C=C/C=N/NC(=O)c2ccc(s2)N+[O-]
InChI
InChI=1S/C12H8N4O6S/c17-12(9-4-6-11(23-9)16(20)21)14-13-7-1-2-8-3-5-10(22-8)15(18)19/h1-7H,(H,14,17)/b2-1+,13-7+Key:IDUMOVRJNBNOTR-BIZLIJPVSA-N
.mw-parser-output .nobold{font-weight:normal}  (verify)

Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.

Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).

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