Neoflavonoid

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title: "Neoflavonoid" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["neoflavonoids"] topic_path: "general/neoflavonoids" source: "https://en.wikipedia.org/wiki/Neoflavonoid" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::figure[src="https://upload.wikimedia.org/wikipedia/commons/c/c8/Neoflavonoid.PNG" caption="Structure of the neoflavonoids backbone (neoflavan represented)"] ::

Neoflavonoids are a class of polyphenolic compounds. While flavonoids (in the narrow sense) have the 2-phenylchromen-4-one backbone, neoflavonoids have the 4-phenylchromen backbone with no hydroxyl group substitution at position 2.

Types

::figure[src="https://upload.wikimedia.org/wikipedia/commons/9/9e/4-phenylcoumarin.svg" caption="Chemical structure of 4-phenylcoumarin (neoflavone backbone)."] ::

Neoflavonoids include 4-arylcoumarins (neoflavones), 4-arylchromanes, dalbergiones and dalbergiquinols.

• Neoflavones The first neoflavone isolated from natural sources was calophyllolide from Calophyllum inophyllum seeds (1951). It is also found in the bark and timber of the plant Mesua thwaitesii, endemic to Sri Lanka.
• Neoflavenes possess the 4-phenylchromen backbone (C15H10O2). Dalbergichromene, extracted from the stem-bark and heartwood of Dalbergia sissoo, is an example of such compounds

Other examples

• Coutareagenin (5-hydroxy-7-methoxy-4-(3,4-dihydroxyphenyl)-2H-benzo-1-pyran-2-on) found in Hintonia latiflora
• Dalbergin
• Nivetin isolated from Echinops niveus

References

References

1. (1966). "The neoflavanoids, a new class of natural products". Experientia.
2. (2000). "Structures of 4-aryl-coumarin (neoflavone) dimers isolated from Pistacia chinensis BUNGE and their estrogen-like activity". Chemical & Pharmaceutical Bulletin.
3. (2003). "Neoflavones. 1. Natural Distribution and Spectral and Biological Properties". Chemistry of Natural Compounds.
4. (1975). "Xanthones and 4-phenylcoumarins of ''Mesua thwaitesii''". Phytochemistry.
5. (March 2019). "Dalbergichromene". Tetrahedron.
6. (2000). "Effects of the neoflavonoid coutareagenin, one of the antidiabetic active substances of Hintonia latiflora, on streptozotocin-induced diabetes mellitus in rats". Arzneimittel-Forschung.
7. (March 2019). "Nivetin, a neoflavonoid from Echinops niveus.". Phytochemistry.

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