NDEL1

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Protein-coding gene in the species Homo sapiens

title: "NDEL1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["human-proteins"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/human-proteins" source: "https://en.wikipedia.org/wiki/NDEL1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.

It plays a significant role in intracellular transport and the process of cellular division via regulation of the dynein motor protein and its cofactor protein, Lis1. Ndel1 is a highly conserved protein and its human gene, NDEL1 is expressed in a wide variety of brain tissues which contributes to neuronal function and development. Nde1 and Ndel1 were in the past referred to as NudE and NudEL respectively. The Nde1 protein is involved in nuclear migration throughout the process of neurogenesis. Studies have revealed that Ndel1 is structurally similar to Nde1 which both play a role in microtubule-based transport. Ndel1 and Nde1 are also thought to be associated with neurodevelopmental and psychiatric disorders. Secondary structure of Ndel1 is composed of various distinct domains: a C-terminal region, and a 200 amino acid N-terminal coiled-coil domain. The coiled-coil domain of Ndel1 serves as a self-associating stable parallel homodimer. Such structural components help with interactions between an array of binding partners, including the motor protein dynein and its cofactor protein, Lis1. Ndel1 forms a heterotetramer complex with Lis1 via the N-terminal coiled-coil domain. The Ndel1 N-terminal coiled-coil domain mediates binding to dynein, whereas the C-terminal domain interacts with Lis1, regulating the activity of the dynein complex.

This gene product is a thiol-activated oligopeptidase and is also known as Endooligopeptidase A in that context. It is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Other Interactions

NDEL1 has been shown to interact with Cyclin-dependent kinase 5, PAFAH1B1

References

References

  1. (Dec 2000). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron.
  2. (Dec 2000). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron.
  3. "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1".
  4. (June 2023). "Ndel1 disfavors dynein–dynactin–adaptor complex formation in two distinct ways". Journal of Biological Chemistry.
  5. (2005-09-01). "Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality". Molecular and Cellular Biology.
  6. (May 2008). "Ndel1 Controls the Dynein-mediated Transport of Vimentin during Neurite Outgrowth". Journal of Biological Chemistry.
  7. (October 2004). "Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning". Neuron.
  8. (April 2010). "LIS1 and NudE Induce a Persistent Dynein Force-Producing State". Cell.
  9. (2011-01-31). "The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein". Journal of Cell Biology.
  10. (2020). "Role of NDE1 in the Development and Evolution of the Gyrified Cortex". Frontiers in Neuroscience.
  11. (2013-10-01). "NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'". BioMolecular Concepts.
  12. (November 2007). "The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of Its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly". Structure.
  13. (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics.
  14. (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics.
  15. (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America.

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human-proteins