Milameline

Quality 0.50 · 2 views · Updated 2 months ago

Chemical compound

title: "Milameline" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["abandoned-drugs", "aldoximes", "m1-receptor-agonists", "m2-receptor-agonists", "m3-receptor-agonists", "m4-receptor-agonists", "m5-receptor-agonists", "oxime-ethers", "tetrahydropyridines"] description: "Chemical compound" topic_path: "arts/music" source: "https://en.wikipedia.org/wiki/Milameline" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| IUPAC_name = (E)-N-methoxy-1-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)methanimine | image = Milameline.png | image_class = skin-invert-image

| tradename = | pregnancy_category = | legal_status = | routes_of_administration =

| bioavailability = | metabolism = | elimination_half-life = | excretion =

| C=8 | H=14 | N=2 | O=1 | smiles = N(/OC)=C\C1=C\CCN(C)C1

Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.

Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.

(1995). "Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences.
(2001). "Muscarinic Receptor Agonists and Antagonists". Molecules.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::