Michael Berridge

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British physiologist and biochemist

title: "Michael Berridge" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["1938-births", "2020-deaths", "alumni-of-gonville-and-caius-college,-cambridge", "british-biochemists", "british-physiologists", "fellows-of-the-academy-of-medical-sciences-(united-kingdom)", "fellows-of-the-american-academy-of-arts-and-sciences", "british-fellows-of-the-royal-society", "fellows-of-trinity-college,-cambridge", "foreign-associates-of-the-national-academy-of-sciences", "knights-bachelor", "fellows-of-the-royal-society-of-biology", "massry-prize-recipients", "people-from-kadoma,-zimbabwe", "recipients-of-the-albert-lasker-award-for-basic-medical-research", "rhodesian-emigrants-to-the-united-kingdom", "rhodesian-people-of-british-descent", "royal-medal-winners", "university-of-zimbabwe-alumni", "white-rhodesian-people", "winners-of-the-heineken-prize", "wolf-prize-in-medicine-laureates", "members-of-academia-europaea", "members-of-the-european-molecular-biology-organization", "international-members-of-the-american-philosophical-society"] description: "British physiologist and biochemist" topic_path: "science/biology" source: "https://en.wikipedia.org/wiki/Michael_Berridge" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary British physiologist and biochemist ::

::data[format=table title="Infobox scientist"]

FieldValue
nameSir Michael Berridge
birth_nameMichael John Berridge
honorific_suffix
birth_date
birth_placeGatooma
Southern Rhodesia
death_date
fieldsPhysiology
Biochemistry
workplacesUniversity of Virginia
Case Western Reserve University
University of Cambridge
Babraham Institute
educationUniversity College of Rhodesia and Nyasaland (Bsc)
University College (PhD)
thesis_titleThe physiology of excretion in the cotton stainer, Dysdercus fasciatus Signoret (Hemiptera, Pyrrhocoridae)
thesis_urlhttps://idiscover.lib.cam.ac.uk/permalink/f/t9gok8/44CAM_ALMA21574338820003606
thesis_year1964
doctoral_advisorVincent Wigglesworth
notable_studentsAntony Galione
known_forCell signaling research
Discovery of inositol trisphosphate as second messenger
awardsKing Faisal International Prize in Science
Louis-Jeantet Prize for Medicine
Knight Bachelor
Canada Gairdner International Award
Albert Lasker Award for Basic Medical Research
Royal Medal
Dr H. P. Heineken Prize for Biochemistry and Biophysics
Shaw Prize in Life Science and Medicine
Wolf Prize in Medicine
::

| name = Sir Michael Berridge | birth_name = Michael John Berridge | honorific_suffix = | image = | image_size = | alt = | caption = | birth_date = | birth_place = Gatooma Southern Rhodesia | death_date = | death_place = | death_cause = | resting_place = | citizenship = | nationality = | fields = Physiology Biochemistry | workplaces = University of Virginia Case Western Reserve University University of Cambridge Babraham Institute | patrons = | education = University College of Rhodesia and Nyasaland (Bsc) University College (PhD) | alma_mater = | thesis_title = The physiology of excretion in the cotton stainer, Dysdercus fasciatus Signoret (Hemiptera, Pyrrhocoridae) | thesis_url = https://idiscover.lib.cam.ac.uk/permalink/f/t9gok8/44CAM_ALMA21574338820003606 | thesis_year = 1964 | doctoral_advisor = Vincent Wigglesworth | doctoral_students = | notable_students = Antony Galione | known_for = Cell signaling research Discovery of inositol trisphosphate as second messenger | awards = King Faisal International Prize in Science Louis-Jeantet Prize for Medicine Knight Bachelor Canada Gairdner International Award Albert Lasker Award for Basic Medical Research Royal Medal Dr H. P. Heineken Prize for Biochemistry and Biophysics Shaw Prize in Life Science and Medicine Wolf Prize in Medicine | spouse = | partner = | children =

Sir Michael John Berridge (22 October 1938 – 13 February 2020) was a British physiologist and biochemist. He was known for his work on cell signaling, in particular the discovery that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane with the release of calcium ions (Ca2+) within the cell.

Early life and education

Berridge was born in Gatooma (now Kadoma, Zimbabwe) in Southern Rhodesia (now Zimbabwe). His high school biology teacher convinced him and his parents that he should pursue tertiary education, and he entered the newly founded University of Rhodesia and Nyasaland (now University of Zimbabwe), earning his Bsc in zoology and chemistry in 1960.

He became interested in insect physiology after helping with his physiology professor's research on tsetse flies, and went to the United Kingdom to study with Vincent Wigglesworth, regarded as the father of insect physiology, at the Department of Zoology of the University of Cambridge. Berridge became a member at the Gonville and Caius College, where Wigglesworth was a fellow, and obtained his PhD in 1965.

Career

Initially intending to return to Southern Rhodesia (now Zimbabwe) after his PhD, Berridge's plan was thwarted by the Rhodesian Bush War. He migrated to the United States instead, joining the Department of Biology of the University of Virginia as a postdoctoral fellow. A year later, he moved to the Developmental Biology Center of Case Western Reserve University. He became a research associate under Bodil Schmidt-Nielsen at the Department of Biology of the same university in 1967.

In 1969, John Treherne invited Berridge to return to the University of Cambridge and join the new Unit of Invertebrate Chemistry and Physiology that he was setting up in the Department of Zoology. He first joined as a senior scientific officer, and was promoted to principal scientific officer in 1972. He became a senior principal scientific officer at the Unit of Insect Neurophysiology and Pharmacology, also at the University of Cambridge, in 1978.

In 1990, Berridge joined the Babraham Institute as the Deputy Chief Scientific Officer of the Laboratory of Molecular Signalling, before serving as the Head of Signalling in 1996 until retiring in 2003. After retirement, Berridge was appointed as Babraham's first emeritus Babraham Fellow.

Berridge was a fellow of the Trinity College of the University of Cambridge from 1972 until his death.

Berridge maintained an online textbook on cell signalling, now hosted by Portland Press under the Biochemical Society.

Research

Berridge had been studying cell signaling when he was at Case Western Reserve University, where he received advice from Theodore W. Rall, co-discoverer of the second messenger cyclic AMP with Earl Wilbur Sutherland Jr., who had also worked at Case Western Reserve. Working on the salivary glands of a blow fly species, Berridge showed cyclic AMP produced the same physiological effect as serotonin, dramatically increasing saliva secretion. The idea of second messenger was new at the time, and his finding supported cyclic AMP as a second messenger of serotonin.

He continued studying cyclic AMP after returning to the University of Cambridge, and conducted experiments to study how serotonin and cyclic AMP affected the movement of ions, as ion concentration difference across the salivary gland epithelium controlled the movement of water across the epithelium through osmosis. Berridge measured the difference in electric potential across the epithelium since ions are charged.

Surprisingly, he found that serotonin and cyclic AMP produced opposite effect to ion movement. While the former reduced the transepithelial potential difference closer to zero, the latter caused an even more negative difference. This suggested cyclic AMP caused positively-charged ions to move across the epithelium from the extracellular fluid to the inside of the salivary gland (known as the lumen).

Berridge suspected calcium ions (Ca2+) could explain the distinct electrical but similar physiological effects of serotonin and cyclic AMP. In 1971, Howard Rasmussen, one of the first researchers to recognise the role of Ca2+ as a second messenger, was on a sabbatical at Cambridge. He and Rasmussen worked together and found serotonin triggered the release of Ca2+ from a storage inside the cell. Later, he confirmed that serotonin activated two distinct receptor system, one through cyclic AMP and the other through Ca2+.

Berridge then wanted to identify the connection between cell surface receptor activation and the release of intracellular Ca2+ from storage. He was inspired by a review article by Robert H. Michell in 1975, which proposed receptor activation caused the breakdown of phosphatidylinositol, which in turn opened Ca2+ channels on the cell membrane to allowing Ca2+ influx into cells. He hypothesised phosphatidylinositol was hydrolysed into a form of inositol phosphate and diglyceride (DAG), and the former was eventually broken down into inositol. He applied lithium ions to blow fly salivary glands to inhibit the conversion of inositol phosphate to inositol.

With help from Rex Malcolm Chaplin Dawson, who was studying inositol at the Babraham Institute near Cambridge, Berridge found that phosphatidylinositol was hydrolysed into IP3 and DAG. Later the same year, he confirmed IP3 released Ca2+ from the intracellular storage, which he identified as the endoplasmic reticulum. This report, together with Yasutomi Nishizuka's discovery that DAG was a second messenger in its own right and could activate protein kinase C, marked the start of the field of calcium signaling.

Awards and honours

The Sir Michael Berridge Prize at the Babraham Institute was named in his honour and established with his endowment.

References

References

  1. (23 February 2020). "Sir Michael Berridge, biochemist behind a paradigm shift in cell science – obituary". [[The Daily Telegraph.
  2. (21 November 2017). "Prof. Dr. Michael J. Berridge". [[Ernst Schering Foundation]].
  3. "Antony Galione". [[New College, Oxford]].
  4. Petersen, Ole H.. (2024). "Sir Michael John Berridge. 22 October 1938 — 13 February 2020". Biographical Memoirs of Fellows of the Royal Society.
  5. (2005). "Unlocking the secrets of cell signaling". [[Annual Review of Physiology]].
  6. "Autobiography of Michael Berridge". [[Shaw Prize]].
  7. "Sir Michael John Berridge". [[Academia Europaea]].
  8. (13 February 2020). "In tribute: Sir Michael Berridge FRS". [[Babraham Institute]].
  9. "The Prize in Life Science & Medicine 2005". Shaw Prize.
  10. "Cell Signalling Biology". [[Biochemical Society]].
  11. (2005). "Interview with Mike Berridge". [[BioEssays]].
  12. (1968). "Insect Salivary Glands: Stimulation of Fluid Secretion by 5-Hydroxytryptamine and Adenosine-3′,5′-monophosphate". [[Science (journal).
  13. (1972). "Transepithelial potential changes during stimulation of isolated salivary glands with 5-hydroxytryptamine and cyclic AMP". [[Journal of Experimental Biology]].
  14. (1972). "Role of Calcium and Adenosine-3′:5′-Cyclic Monophosphate in Controlling Fly Salivary Gland Secretion". [[Proceedings of the National Academy of Sciences of the United States of America]].
  15. (1981). "Electrophysiological evidence for the existence of separate receptor mechanisms mediating the action of 5-hydroxytryptamine". [[Molecular and Cellular Endocrinology]].
  16. (1975). "Inositol phospholipids and cell surface receptor function". [[Biochimica et Biophysica Acta#Modern journal.
  17. (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". [[Biochemical Journal]].
  18. (1983). "Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate". [[Nature (journal).
  19. (1984). "The role of protein kinase C in cell surface signal transduction and tumour promotion". Nature.
  20. (2003). "Calcium signalling: dynamics, homeostasis and remodelling". [[Nature Reviews Molecular Cell Biology]].
  21. "Michael Berridge". [[Royal Society]].
  22. "Professor Michael J. Berridge". [[King Faisal Prize]].
  23. (October 2017). "Professor Michael BERRIDGE". [[Louis-Jeantet Foundation]].
  24. "Michael J. Berridge". [[Gairdner Foundation]].
  25. "Sir Michael Berridge". [[Academia Europaea]].
  26. "1989 Albert Lasker Basic Medical Research Award". [[Lasker Award]].
  27. "Michael J. Berridge". [[European Molecular Biology Organization]].
  28. "BERRIDGE Michael". Royal Academy of Medicine of Belgium (Académie royale de médecine de Belgique).
  29. "Award winners : Royal Medal". [[Royal Society]].
  30. "Sir Michael J. Berridge". [[Heineken Prizes]].
  31. (10 December 2018). "Michael J. Berridge". [[Wolf Foundation]].
  32. "Massry Prize Winners ( 1996 – Present )".
  33. {{London Gazette. (30 December 1997)
  34. (4 November 1998). "Gonville and Caius College". [[Cambridge University Reporter]].
  35. "Sir Michael Berridge FRS FMedSci". [[Academy of Medical Sciences]].
  36. "Michael J. Berridge". [[Ernst Schering Foundation]].
  37. "Michael J. Berridge". [[National Academy of Sciences]].
  38. (31 May 2023). "Michael John Berridge". [[American Academy of Arts and Sciences]].
  39. "Honorary Members". [[Biochemical Society]].
  40. "Sir Michael J. Berridge". [[American Philosophical Society]].
  41. "The Sir Michael Berridge Prize". Babraham Institute.

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