Mibolerone

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Chemical compound

title: "Mibolerone" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["abandoned-drugs", "tertiary-alcohols", "androgens", "estranes", "hepatotoxins", "enones", "progestogens"] description: "Chemical compound" topic_path: "arts/music" source: "https://en.wikipedia.org/wiki/Mibolerone" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Verifiedfields = verified | Watchedfields = verified | verifiedrevid = 462252160 | IUPAC_name = (7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one | image = Mibolerone structure.png | image_class = skin-invert-image | width = 225px | image2 = Mibolerone molecule ball.png | image_class2 = bg-transparent | width2 = 235px

| tradename = Cheque Drops, Matenon | Drugs.com = | pregnancy_category = | legal_BR = C5 | legal_BR_comment = | legal_CA = Schedule IV | legal_US = Schedule III | legal_status = | routes_of_administration = By mouth | class = Androgen; Anabolic steroid; Progestogen

| bioavailability = | protein_bound = | metabolism = Liver | elimination_half-life = | excretion =

| CAS_number_Ref = | CAS_number = 3704-09-4 | ATC_prefix = None | ATC_suffix = | PubChem = 251636 | IUPHAR_ligand = 2859 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 220460 | UNII_Ref = | UNII = 9OGY4BOR8D | KEGG_Ref = | KEGG = D05025 | ChEBI_Ref = | ChEBI = 34849 | ChEMBL_Ref = | ChEMBL = 425863 | synonyms = U-10997; CDB-904; Dimethylnandrolone; Dimethylnortestosterone; DMNT; 7α,17α-Dimethyl-19-nortestosterone; 7α,17α-Dimethylestr-4-en-17β-ol-3-one

| C=20 | H=30 | O=2 | SMILES = C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@@H]3[C@@H]1[C@@H]4CCC@(C)O | StdInChI_Ref = | StdInChI = 1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = PTQMMNYJKCSPET-OMHQDGTGSA-N

Mibolerone, also known as dimethylnortestosterone (DMNT) and sold under the brand names Cheque Drops and Matenon, is a synthetic, orally active, and extremely potent anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was marketed by Upjohn for use as a veterinary drug. It was indicated specifically as an oral treatment for prevention of estrus (heat) in adult female dogs.

Side effects

Pharmacology

Pharmacodynamics

Mibolerone has both higher affinity and greater selectivity for the androgen receptor (AR) than does the related potent AAS metribolone (17α-methyl-19-nor-δ9,11-testosterone), although potent and significant progestogenic activity remains present. However, another study found that mibolerone and metribolone had similar affinity for the progesterone receptor (PR) but that mibolerone only had around half the affinity of metribolone for the AR.

::data[format=table title="class="nowrap" | Relative affinities (%) of mibolerone and related steroids{{cite journal | vauthors = Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP | title = Steroid flexibility and receptor specificity | journal = J. Steroid Biochem. | volume = 13 | issue = 1 | pages = 45–59 | date = January 1980 | pmid = 7382482 | doi = 10.1016/0022-4731(80)90112-0 }}{{cite journal | vauthors = Ojasoo T, Delettré J, Mornon JP, Turpin-VanDycke C, Raynaud JP | title = Towards the mapping of the progesterone and androgen receptors | journal = J. Steroid Biochem. | volume = 27 | issue = 1–3 | pages = 255–69 | date = 1987 | pmid = 3695484 | doi = 10.1016/0022-4731(87)90317-7 }}"] | Compound || Chemical name || || || || || | |---| | Testosterone | | Nandrolone | | Trenbolone | | Trestolone | | Normethandrone | | Metribolone | | Mibolerone | | Dimethyltrienolone | | Values are percentages (%). Reference ligands (100%) were progesterone for the , testosterone for the , estradiol for the , for the , and aldosterone for the . | ::

Chemistry

Mibolerone, also known as 7α,17α-dimethyl-19-nortestosterone (DMNT) or as 7α,17α-dimethylestr-4-en-17β-ol-3-one, is a synthetic estrane steroid and a 17α-alkylated derivative of nandrolone (19-nortestosterone). It is the 17α-methyl derivative of trestolone (7α-methyl-19-nortestosterone; MENT). Other related AAS include metribolone (17α-methyl-δ9,11-19-nortestosterone) and dimethyltrienolone (7α,17α-dimethyl-δ9,11-19-nortestosterone).

Synthesis

The original patented synthesis was revised: Precursor (also needed for Plomestane): ::figure[src="https://upload.wikimedia.org/wikipedia/commons/5/53/Mibolerone_synthesis_(2007).svg" caption=""] ::

The reaction of Bolandione [734-32-7] (1) with triethyl orthoformate gave 3-Ethoxyestra-3,5-dien-17-one [2863-88-9] (2) in 64% yield. Organometallic reaction with methyl lithium followed by hydrolysis of the dienol ether gave Normethandrone [514-61-4] (5) in 40% yield. In an alternative synthesis, reaction of Estr-5(10)-ene-3,17-dione [3962-66-1] (3) with methanol catalyzed by malonic acid gave a near quantitivate yield of the ketal, 3,3-dimethoxyestr-5(10)-en-17-one [19257-34-2] (4). Reaction with the organometallic reagent and hydrolysis in this case afforded a much higher yield of product (86.7%) than in the first case. Oxidation with chloranil afforded a 75.6% yield of 17-methyl-6-dehydronandrolone (6). Conjugate addition of methyl lithium in the presence of cuprous iodide (c.f. Gillman reagent) gave a 72.5% yield of mibolerone (7). ::figure[src="https://upload.wikimedia.org/wikipedia/commons/3/35/Miboleronesynthesis.svg" caption="3341557}} (1962, 1967 both to [[Upjohn]])."] ::

In the other synthesis heating nandrolone acetate [1425-10-1] (1) with chloranil gives 6-Dehydronandrolone Acetate [2590-41-2] (2), and reaction of that compound with methylmagnesium bromide in the presence of cuprous chloride gives (after saponification), Trestolone (7alpha-Methylnandrolone) [3764-87-2] (3). The alcohol at C17 is then oxidized to a ketone, Mentabolan [17000-78-1] (4). Enamines are commonly used to activate adjacent functions; they are also not infrequently used, as in this case, as protecting groups. Thus, reaction of the intermediate with pyrrolidine gives dienamine PC135056261 (5). This transformation emphasizes the clear difference in reactivity between ketones at C7 and C17. A second methyl Grignard addition gives the corresponding 17α-methyl derivative. Hydrolysis of the enamine function then affords mibolerone (6).

For SAR purposes compare for bolasterone and calusterone.

History

Mibolerone was first synthesized in 1963.

Society and culture

Generic names

Mibolerone is the generic name of the drug and its , , and . It is also known as dimethylnortestosterone (DMNT) and by its former developmental code name U-10997.

Brand names

Mibolerone has been marketed under the brand names Cheque Drops and Matenon.

References

References

  1. Anvisa. (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (31 October 1999). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer Science & Business Media.
  3. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  4. (January 2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
  5. William Llewellyn. (2011). "Anabolics". Molecular Nutrition Llc.
  6. (1986). "Characterization of steroid receptors in human prostate using mibolerone". Prostate.
  7. (1984). "The use of radioactive 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) in the assay of androgen receptors". Prostate.
  8. (1992). "A comparison of progestin and androgen receptor binding using the CoMFA technique". J. Comput.-Aided Mol. Des..
  9. (January 1980). "Steroid flexibility and receptor specificity". J. Steroid Biochem..
  10. (1987). "Towards the mapping of the progesterone and androgen receptors". J. Steroid Biochem..
  11. (1997). "Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays". Methods Find Exp Clin Pharmacol.
  12. (August 2007). "Synthesis and characterization of mibolerone". Journal of Central South University of Technology.
  13. Dai Jing & Li Lianwu, CN103601781 (2014 to Zhejiang Xianju Pharmaceutical Co Ltd).
  14. {{Cite patent. 3341557 (1962, 1967 both to [[Upjohn]]).
  15. (1996). "Metabolism of anabolic androgenic steroids". Clin. Chem..

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abandoned-drugstertiary-alcoholsandrogensestraneshepatotoxinsenonesprogestogens