Methanofuran

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title: "Methanofuran" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["amines", "peptides", "coenzymes", "furans"] topic_path: "general/amines" source: "https://en.wikipedia.org/wiki/Methanofuran" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::figure[src="https://upload.wikimedia.org/wikipedia/commons/e/e5/Methanofuran_a_b_c.svg" caption="Structure of the methanofurans"] ::

Methanofurans (MFRs) are a family of chemical compounds found in methanogenic archaea. These species feature a 2-aminomethylfuran linked to phenoxy group. At least three different end groups are recognized: R = tricarboxyheptanoyl (methanofuran), glutamyl-glutamyl (methanofuran b), tricarboxy-2-hydroxyheptanoyl (methanofuran c, see picture).

Formylation of MFR

Methanofuran converts to formylmethanofuran in an early stage of methanogenesis. The enzyme formylmethanofuran dehydrogenase (EC: 1.2.99.5) formylates methanofuran using , the primary C1 source in methanogenesis.

Deformylation of MFR

The enzyme formylmethanofuran:tetrahydromethanopterin formyltransferase catalyzes the transfer of the formyl group from formylmethanofuran to N5 on tetrahydromethanopterin, . This enzyme has been crystallized; it contains no prosthetic group.

References

Thauer RK. (September 1998). "Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture". Microbiology.
(September 1997). "The active species of {{chem". Eur. J. Biochem..
(March 2006). "The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes". J. Mol. Biol..

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