MAP2K6

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Protein-coding gene in the species Homo sapiens

title: "MAP2K6" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["ec-2.7.12"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/ec-2-7-12" source: "https://en.wikipedia.org/wiki/MAP2K6" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Main article: Mitogen-activated protein kinase kinase

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

Function

MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.

Interactions

MAP2K6 has been shown to interact with TAOK2, ASK1, MAPK14 and MAP3K7.

References

References

  1. (Feb 1996). "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)". The Journal of Biological Chemistry.
  2. "Entrez Gene: MAP2K6 mitogen-activated protein kinase kinase 6".
  3. (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry.
  4. (Jun 2003). "Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)". Molecular Cell.
  5. (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal.
  6. (May 2003). "p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels". Molecular and Cellular Biology.
  7. (Mar 1996). "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway". Molecular and Cellular Biology.
  8. (May 1996). "Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade". The Journal of Biological Chemistry.
  9. (Dec 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". The EMBO Journal.
  10. (Jul 2001). "TAK1 is a ubiquitin-dependent kinase of MKK and IKK". Nature.
  11. (Mar 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature.
  12. (Jun 2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Letters.

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