Maneb

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title: "Maneb" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["aldehyde-dehydrogenase-inhibitors", "dithiocarbamates", "fungicides", "manganese(ii)-compounds", "monoaminergic-neurotoxins", "polymers"] topic_path: "science/chemistry" source: "https://en.wikipedia.org/wiki/Maneb" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 434399765 | ImageFile = Maneb.svg | ImageClass = skin-invert-image | ImageAlt = | IUPACName = [2-[(Dithiocarboxy)amino]ethyl]carbamodithioato](2-dithiocarboxy-amino-ethyl-carbamodithioato)(2-)-kS,kS']manganese | OtherNames = Manganese ethylene-1,2-bisdithiocarbamate, polymer |Section1={{Chembox Identifiers | CASNo = 12427-38-2 | CASNo_Ref = | UNII_Ref = | UNII = K221E12G7T | InChI = 1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2 | InChIKey = YKSNLCVSTHTHJA-UHFFFAOYSA-L | PubChem = 3032581 | MeSHName = Maneb | SMILES = [Mn+]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)[S-] | ChemSpiderID_Ref = | ChemSpiderID = 2297517 }} |Section2={{Chembox Properties | Formula = (C4H6MnN2S4)n | Appearance = Yellow to brown colored crystalline solid | Density = 1.92 g/cm3 | MeltingPtC = 192 to 204 | MeltingPt_notes = (decomposes) | BoilingPt = | Solubility = 160 mg/L }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | GHSPictograms = | AutoignitionPt = }}

Maneb (manganese ethylene-bis-dithiocarbamate) is a fungicide and a polymeric complex of manganese with the ethylene bis (dithiocarbamate) anionic ligand.

Health effects

Exposure to maneb can occur when breathed in; it can irritate the eyes, nose, and throat as well as cause headache, fatigue, nervousness, dizziness, seizures and even unconsciousness. Prolonged or long-term exposure may interfere with the function of the thyroid. Exposure to maneb is also shown to induce a Parkinson's disease like neurotoxicity in mice. The link between maneb and Parkinson's disease had been suspected since the early 2000s; however, a 2022 review concluded that maneb, alongside other pesticides like MPTP, paraquat, and rotenone, play a prominent role in the development of the disease. More investigation is needed to investigate its underlying mechanism of action.

Production

Manganese(II) ethylenebis(dithiocarbamate) of low ethylenethiourea (ETU) content is prepared by mixing disodium ethylenebis (dithiocarbamate) with formaldehyde in aqueous medium then mixing a water-soluble manganese(II) salt to precipitate the maneb. The product can be further formulated with a metal salt and also with paraformaldehyde. (See External links for the patent citation)

Applications

Maneb, is a broad spectrum fungicide that is extensively applied against a wide range of fungal pathogens affecting ornamental plants, food and feed crops. It can also be used to create a toxin-based animal model of Parkinson's disease, usually in primates.

Environmental effects

Regulation

Maneb was included in a pesticide ban proposed by the Swedish Chemicals Agency and approved by the European Parliament on January 13, 2009.

References

References

  1. (June 2000). "Ullmann's Encyclopedia of Industrial Chemistry".
  2. (2022-12-01). "Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis".). Chemosphere.
  3. "MANEB". New Jersey Department of Health and Senior Services.
  4. (April 2009). "Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California". American Journal of Epidemiology.
  5. (September 2022). "Neurotoxicity of pesticides - A link to neurodegeneration". Ecotoxicol Environ Saf.
  6. (July 2004). "Simultaneous determination of maneb and its main metabolites in tomatoes by liquid chromatography using diode array ultraviolet absorbance detection". Journal of Chromatography A.
  7. (September 2009). "Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?". Trends in Pharmacological Sciences.
  8. (2008-09-23). "Interpretation of criteria for approval of active substances in the proposed EU plant protection regulation". Swedish Chemicals Agency (KemI).
  9. (2009-01-13). "MEPs approve pesticides legislation".

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aldehyde-dehydrogenase-inhibitorsdithiocarbamatesfungicidesmanganese(ii)-compoundsmonoaminergic-neurotoxinspolymers