Leteprinim

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Chemical compound

title: "Leteprinim" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["anilides", "benzoic-acids", "nootropics", "purines"] description: "Chemical compound" topic_path: "general/anilides" source: "https://en.wikipedia.org/wiki/Leteprinim" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| verifiedrevid = 444252852 | IUPAC_name = 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid | image = Leteprinim.svg | image_class = skin-invert-image | width = 240

| tradename = | routes_of_administration =

| elimination_half-life =

| CAS_number_Ref = | CAS_number = 138117-50-7 | ATC_prefix = none | ATC_suffix = | PubChem = 132123 | DrugBank_Ref = | UNII_Ref = | UNII = NBY3IU407M

| C=15 | H=13 | N=5 | O=4 | smiles = C1=CC(=CC=C1C(=O)O)NC(=O)CCN2C=NC3=C2NC=NC3=O | ChemSpiderID = 116710 | StdInChI = 1S/C15H13N5O4/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22) | StdInChIKey = JMPOIZCOJJMTHI-UHFFFAOYSA-N

Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects. It stimulates release of nerve growth factors and enhances survival of neurons in the brain, and is under development as a potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke.

References

References

  1. (June 2001). "AIT-082 is neuroprotective against kainate-induced neuronal injury in rats". Experimental Neurology.
  2. (April 2000). "Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin". Annals of the New York Academy of Sciences.
  3. (April 2003). "Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones". Psychopharmacology.
  4. (August 1999). "AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury". Expert Opinion on Investigational Drugs.
  5. (2002). "The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats". Restorative Neurology and Neuroscience.
  6. (November 2003). "Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin". Molecular and Cellular Neurosciences.
  7. (2004). "AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats". International Journal of Immunopathology and Pharmacology.
  8. (March 2006). "Protection of sensory function in diabetic rats by Neotrofin". European Journal of Pharmacology.
  9. (September 2002). "Brain metabolic effects of Neotrofin in patients with Alzheimer's disease". Brain Research.
  10. (July 2004). "Drugs in development for Parkinson's disease". Current Opinion in Investigational Drugs.

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anilidesbenzoic-acidsnootropicspurines