Kveim test

Quality 0.50 · 0 views · Updated 2 months ago

title: "Kveim test" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["skin-tests"] topic_path: "general/skin-tests" source: "https://en.wikipedia.org/wiki/Kveim_test" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::data[format=table title="Infobox diagnostic"]

FieldValue
NameKveim test
MeshIDD007731
SynonymsKveim-Siltzbach test
::

| Name = Kveim test | Image = | Caption = | ICD10 = | ICD9 = | MeshID = D007731 | OPS301 = | Synonyms = Kveim-Siltzbach test The Kveim test, Nickerson-Kveim or Kveim-Siltzbach test is a skin test used to detect sarcoidosis, where part of a spleen from a patient with known sarcoidosis is injected into the skin of a patient suspected to have the disease. If non caseating granulomas are found (four to six weeks later), the test is positive. If the patient has been on treatment (e.g., glucocorticoids), the test may return a false negative result. The test is not commonly performed, and in the UK no substrate has been available since 1996. There is a concern that certain infections, such as bovine spongiform encephalopathy, could be transferred through a Kveim test.

It is named for the Norwegian pathologist Morten Ansgar Kveim, who first reported the test in 1941 using lymph node tissue from sarcoidosis patients. It was popularised by the American physician Louis Siltzbach, who introduced a modified form using spleen tissue in 1954. Kveim's work was a refinement of earlier studies performed by Nickerson, who in 1935 first reported on skin reactions in sarcoid.

A Kveim test may be used to distinguish sarcoidosis from conditions with otherwise indistinguishable symptoms such as berylliosis.{{Cite journal |title=The uses and adverse effects of beryllium on health |journal=Indian Journal of Occupational and Environmental Medicine |first1=Ross G. |last1=Cooper |first2=Adrian P. |last2=Harrison |date=August 2009 |volume=13 |issue=2 |pages=65–76 |doi=10.4103/0019-5278.55122 |pmc=2847329 |pmid=20386622 |doi-access=free

References

References

  1. {{Cite GPnotebook. -389021680. Kveim test
  2. Kveim MA. (1941). "En ny og spesifikk kutan-reaksjon ved Boecks sarcoid. En foreløpig meddelelse". Nordisk Medicin.
  3. {{WhoNamedIt. synd. 556
  4. (1954). "The Nickerson-Kveim reaction in sarcoidosis". Am. J. Med..
  5. (1935). "Skin reactions in sarcoid". Proc. Soc. Exp. Biol. Med..

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::

skin-tests