JunD

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Protein-coding gene in the species Homo sapiens

title: "JunD" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["transcription-factors"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "arts/film" source: "https://en.wikipedia.org/wiki/JunD" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Transcription factor JunD is a protein that in humans is encoded by the JUND gene.

Function

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.

{{anchor|Delta JunD}}ΔJunD

The dominant negative mutant variant of JunD, known as ΔJunD or Delta JunD, is a potent antagonist of the ΔFosB transcript, as well as other forms of AP-1-mediated transcriptional activity. In the nucleus accumbens, ΔJunD directly opposes many of the neurological changes that occur in addiction (i.e., those induced by ΔFosB). ΔFosB inhibitors (drugs that oppose its action) may be an effective treatment for addiction and addictive disorders. Being an unnatural genetic variant, ΔJunD has not been observed in humans.

Interactions

JunD has been shown to interact with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1.

References

References

  1. (July 1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res..
  2. (June 1991). "Structure and function of human jun-D". Oncogene.
  3. "Entrez Gene: JUND jun D proto-oncogene".
  4. (2006). "Neural mechanisms of addiction: the role of reward-related learning and memory". Annu. Rev. Neurosci..
  5. (November 2011). "Transcriptional and epigenetic mechanisms of addiction". Nat. Rev. Neurosci..
  6. (October 2010). "ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward". Genes Brain Behav..
  7. (2009). "Molecular Neuropharmacology: A Foundation for Clinical Neuroscience". McGraw-Hill Medical.
  8. (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Mol. Endocrinol..
  9. (January 1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell.
  10. (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol..
  11. (June 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev..

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transcription-factors