Intersectin 1

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Protein-coding gene in the species Homo sapiens

title: "Intersectin 1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["eh-domain-containing-proteins"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/eh-domain-containing-proteins" source: "https://en.wikipedia.org/wiki/Intersectin_1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.

Function

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.

Interactions

ITSN1 has been shown to interact with:

References

References

  1. (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics.
  2. (Nov 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry.
  3. "Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)".
  4. (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology.
  5. (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology.
  6. (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry.
  7. (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry.
  8. (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal.

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