Ilaprazole

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Stomach acid suppressing medication

title: "Ilaprazole" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["benzimidazoles", "proton-pump-inhibitors", "pyridines", "pyrroles", "sulfoxides", "aromatic-ethers", "methoxy-compounds", "phenol-ethers"] description: "Stomach acid suppressing medication" topic_path: "general/benzimidazoles" source: "https://en.wikipedia.org/wiki/Ilaprazole" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Stomach acid suppressing medication ::

| IUPAC_name = 2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole | image = Ilaprazole.svg | image_class = skin-invert-image | width = 250 | alt = | caption = | tradename = Noltec | pregnancy_AU = | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = A02 | ATC_suffix = BC11

| legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number = 172152-36-2 | PubChem = 214351 | DrugBank = | ChEMBL = 2106370 | UNII_Ref = | UNII = 776Q6XX45J | ChemSpiderID = 185839 | KEGG = D13013

| C=19 | H=18 | N=4 | O=2 | S=1 | smiles = Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4 | StdInChI = 1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22) | StdInChIKey = HRRXCXABAPSOCP-UHFFFAOYSA-N

Ilaprazole (trade name Noltec) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

It is available in strengths of 5, 10, and 20 mg.

Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole is developed by Il-Yang Pharmaceutical (Korea), and is still under clinical trials with US FDA. It has launched in Korea and China for the treatment of gastric ulcer, duodenal ulcer, gastroesophageal reflux disease and erosive esophagitis.

Ilaprazole is sold in Mexico by Chinoin Pharmaceuticals under the brand name Norutec.

References

References

  1. (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy.
  2. (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology.
  3. (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology.
  4. {{ClinicalTrialsGov. NCT00952978. Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)
  5. "Norutec". Chinoin Pharmaceuticals.

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benzimidazolesproton-pump-inhibitorspyridinespyrrolessulfoxidesaromatic-ethersmethoxy-compoundsphenol-ethers