ICP8

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title: "ICP8" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["simplexviruses", "viral-nonstructural-proteins"] topic_path: "general/simplexviruses" source: "https://en.wikipedia.org/wiki/ICP8" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of double-stranded DNA (dsDNA); its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent. In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.{{cite journal|pmid=12021322|year=2002|last1=Zhou|first1=C|last2=Knipe|first2=DM|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme|volume=76|issue=12|pages=5893–904|pmc=136207|journal=Journal of Virology|doi=10.1128/JVI.76.12.5893-5904.2002

References

References

  1. (1993). "Herpes simplex virus type 1 ICP8: Helix-destabilizing properties". Journal of Virology.

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simplexvirusesviral-nonstructural-proteins