HSPA4
Protein-coding gene in the species Homo sapiens
title: "HSPA4" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["heat-shock-proteins"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/heat-shock-proteins" source: "https://en.wikipedia.org/wiki/HSPA4" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein-coding gene in the species Homo sapiens ::
Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.
The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family. However it is now known that human HSPA4 is an equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.
Interactions
HSPA4 has been shown to interact with:
- APAF1
- DNAJB1,
- HDAC1,
- HSF1,
- HSPBP1,
- Histone deacetylase 2,
- NAD(P)H dehydrogenase (quinone 1),
- STUB1, and
- TTC1.
References
References
- (Jul 1993). "Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5". Journal of Immunology.
- "Entrez Gene: HSPA4 heat shock 70kDa protein 4".
- (Apr 1997). "Cloning of apg-2 encoding a novel member of heat shock protein 110 family". Gene.
- (Aug 2000). "Negative regulation of the Apaf-1 apoptosome by Hsp70". Nature Cell Biology.
- (Mar 2002). "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70". The Journal of Biological Chemistry.
- (Dec 1996). "A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress & Chaperones.
- (Jul 1992). "The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression". Genes & Development.
- (Apr 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1". The Journal of Biological Chemistry.
- (Jun 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Molecular and Cellular Biology.
- (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Molecules and Cells.
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