HSD17B2

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Protein-coding gene in the species Homo sapiens

title: "HSD17B2" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/HSD17B2" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

Function

17β-HSD2 is involved in inactivation of androgens and estrogens, being accurately describable as "antiandrogenic" and "antiestrogenic", and is the key 17β-HSD isozyme in androgen and estrogen inactivation. Specific reactions catalyzed by 17β-HSD2 include estradiol to estrone, testosterone to androstenedione, and androstenediol to . In addition to 17β-HSD activity, this enzyme also shows high 20α-hydroxysteroid dehydrogenase activity and can activate the weak progestogen 20α-hydroxyprogesterone into the potent progestogen progesterone.

Expression

17β-HSD2 is widely expressed throughout the body including in the placenta, liver, intestines, endometrium, kidney, pancreas, breast, prostate, bone, and many other tissues.

Clinical significance

Polymorphisms in HSD17B2 have been associated with breast cancer and prostate cancer. 17β-HSD2 activity has also been associated with endometriosis and osteoporosis, and inhibitors of the enzyme are of potential interest in the treatment of the latter condition. Inactivating mutations resulting in a syndrome of congenital deficiency of 17β-HSD2 have not been reported to date.

References

References

  1. (Feb 1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2". Genomics.
  2. (Mar 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions.
  3. "Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2".
  4. (2006). "Multifunctionality of human 17beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol..
  5. (2016). "High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract". Journal of Cancer.
  6. (2004). "The role of 17 beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol..
  7. (May 2017). "Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer". Oncotarget.
  8. (9 November 2016). "Hormones, Brain and Behavior". Elsevier Science.
  9. (2009). "Integrated view on 17beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol..
  10. (2010). "17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis". Semin. Reprod. Med..
  11. (2011). "17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development". J. Steroid Biochem. Mol. Biol..
  12. (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis". Future Med Chem.
  13. J. Larry Jameson. (13 July 1998). "Principles of Molecular Medicine". Springer Science & Business Media.

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