HLA-DR8
title: "HLA-DR8" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR8" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
Serology
The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations
DR8 is linked to papillary thyroid carcinomas, early onset pauciarticular juvenile chronic arthritis, primary biliary cirrhosis
by allele
HLA-DRB1*0801 is linked to primary biliary cirrhosis In Mexicans DR8 is found more often in type-2 juvenile diabetes.
HLA-DRB1*0803 is also linked to primary biliary cirrhosis
Genetic Linkage
::data[format=table]
| DRA | DRB1 | DQA1 | DQB1 | DRB1 | HLA-A | HLA-B | DRB1 |
|---|---|---|---|---|---|---|---|
| Haplotypes | *0101 | *0801 | *0101 | ||||
| Haplotypes | *0401 | *0402 | *0801 | ||||
| Haplotypes | *0000 | *0000 | *0801 | ||||
| :: |
HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
References
References
- [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
- DR12 - 3%
- (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol.
- (1994). "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol.
- (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol.
- (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology.
- (2005). "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol.
- (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". [[Pediatric Diabetes]].
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