HLA-DR18
title: "HLA-DR18" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR18" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.
Serology
DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.
Disease associations
DR18 seropositivity is associated with rheumatoid polyarthritis
DRB1*0302 is positively associated with juvenile diabetes, nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.
Genetic Linkage
::data[format=table]
| Serotypes | DRA | DRB1 | DRB3 | DQA1 | DQB1 | DRB1 | HLA-A | HLA -B | DRB1 |
|---|---|---|---|---|---|---|---|---|---|
| DR18(3)-DR52 | *0101 | *0302 | *0101 | ||||||
| D18(3)-DQ2(2.5) | *0501 | *0201 | *0302 | ||||||
| A33-B58-DR18(3) | *3301 | *5801 | *0302 | ||||||
| :: |
HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA10501 and HLA DQB10201 alleles.
References
References
- [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
- (1997). "[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]". Dakar Med.
- (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratislavské Lekárske Listy.
- (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain.
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