HLA-DQ9
title: "HLA-DQ9" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dq-haplotypes", "human-mhc-mediated-diseases"] topic_path: "general/hla-dq-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DQ9" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox heteroisoform"]
| Field | Value |
|---|---|
| isoformgroup | HLA-DQ9 |
| polymer_type | MHC Class II, DQ cell surface antigen |
| image | DQ_Illustration.PNG |
| image_source | Illustration of HLA-DQ with bound peptide. |
| isoformCount | 2 |
| subunit1 | DQA1 |
| subunit2 | DQB1 |
| isoform1 | DQ α2β9 |
| nick1 | DQ9.2 |
| allele1a | |
| allele1b | *0303 |
| isoform2 | DQ α3β9 |
| nick2 | DQ9.3 |
| allele2a | |
| allele2b | *0303 |
| rareIsoforms | 0 |
| :: |
| isoformgroup = HLA-DQ9 | polymer_type = MHC Class II, DQ cell surface antigen | image = DQ_Illustration.PNG | image_source = Illustration of HLA-DQ with bound peptide. | isoformCount = 2 | subunit1 = DQA1 | subunit2 = DQB1 | isoform1 = DQ α2β9 | nick1 = DQ9.2 | allele1a = | allele1b = *0303 | isoform2 = DQ α3β9 | nick2 = DQ9.3 | allele2a = | allele2b = *0303 | rareIsoforms = 0 HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.
Serology
::data[format=table title="DQ2, DQ3, DQ7, DQ8, and DQ9 recognition of DRB1*0303 product[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]"]
| Alleles link-out to IMGT/HLA Databease at EBI |
|---|
| :: |
The serotyping efficiency of DQ9 is poor. The recognition of DQB10303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB10303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.
DQB1*0303
(DQ9) is associated with nasal polyps, gestational diabetes, microscopic polyangiitis (Japanese). Primary linkage is with DRB10901-DQB10303
Haplotypes and disease
DQ9.2
DQA10201:DQB10303 is associated with type I psoriasis (vulgaris),
DQ9.3
DQA10302:DQB10303 maybe associated with juvenile diabetes in the orient. (Chinese) Primary linkage of vitiligo is with DQA103-DQB10303.
References
References
- [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
- (2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol..
- (2004). "Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population". Hum. Immunol..
- (2006). "Association of HLA-DRB10901-DQB10303 haplotype with microscopic polyangiitis in Japanese". Genes Immun..
- (1993). "Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB10701/2, -DQA10201, -DQB1*0303 extended haplotype". J. Invest. Dermatol..
- (2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. Dermatol..
- (1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". Diabetes Res. Clin. Pract..
- (1992). "Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab..
- (2006). "MHC haplotypic association in Chinese Han patients with vitiligo". Journal of the European Academy of Dermatology and Venereology.
::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::