Hexetidine

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Anti-bacterial agent

title: "Hexetidine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["oral-hygiene", "pyrimidines", "dental-drugs"] description: "Anti-bacterial agent" topic_path: "general/oral-hygiene" source: "https://en.wikipedia.org/wiki/Hexetidine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Anti-bacterial agent ::

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 447134056 | IUPAC_name = 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine | image = Hexetidine.svg | image_class = skin-invert-image

| tradename = Bactidol, others | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = Not to be used by pregnant women | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = OTC | routes_of_administration = Topical (mouthwash)

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref = | CAS_number = 141-94-6 | ATC_prefix = A01 | ATC_suffix = AB12 | ATC_supplemental = | PubChem = 3607 | DrugBank_Ref = | DrugBank = DB08958 | UNII_Ref = | UNII = 852A84Y8LS | ChEMBL_Ref = | ChEMBL = 144673 | ChemSpiderID_Ref = | ChemSpiderID = 32697287

| C=21 | H=45 | N=3 | smiles = CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)C | StdInChI_Ref = | StdInChI = 1S/C22H46N2/c1-7-11-13-20(9-3)15-23-17-22(5,6)18-24(19-23)16-21(10-4)14-12-8-2/h20-21H,7-19H2,1-6H3 | StdInChIKey_Ref = | StdInChIKey = ZSHBZCXOMHHPCE-UHFFFAOYSA-N

Hexetidine is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a local anesthetic, astringent and deodorant and has antiplaque effects.

Hexetidine (then as insecticide) patent application was filed in 1945 and granted in 1947 to Murray Senkus of Commercial Solvents Corporation.

Hexetidine is the medicinal ingredient in Sterisol, which is labelled for the symptomatic treatment of: streptococcal pharyngitis ('strep throat'), tonsillitis, pharyngitis, laryngitis, gingivitis, ulcerative stomatitis, oral thrush and Vincent's angina; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is not the same as Chlorhexidine, another chemical commonly used in mouthwash, or the antimicrobial drug Hexedene (C22H45N3).

In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. In Canada, hexetidine was the active ingredient in the medicated mouthwash branded Steri/sol which has been discontinued. It used to be produced by McNeil Consumer Healthcare, a division of Johnson & Johnson (originally Warner–Lambert, then marketed by Pfizer after its acquisition since 2007). Oraldene contains 0.1 g/100 ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40 ml named Hexoral (by Mcneil) also contains 0.2% hexetidine as its active compound. In Greece it is called Hexalen mouth wash (also available in spray). Hexetidine can also be found in the mouthwash Bactidol (by Mcneil) which is sold in many Asian countries. In Germany, hexetidine vaginal suppositories branded Vagi-Hex are available to be used for vaginal antisepsis. They are also used in late pregnancy for reducing neonatal infectious mortality and morbidity due to group B streptococcal infections; nonetheless, hexetidine is to be used with care during pregnancy, and its vaginal use is counter-indicated in the first three months of pregnancy.

::figure[src="https://upload.wikimedia.org/wikipedia/commons/5/5c/Hexetidine.png" caption="Hexetidine"] ::

References

References

  1. (2002). "Hexetidine--an oral antiseptic". Med Arh.
  2. (28 Jan 1947). "UNITED STATES PATENT OFFICE 2,415,047 INSECT-CONTROLLING COMPOSITIONS AND METHOD FOR CONTROLLING IN­SECTS THEREBY".
  3. "Hexedine | CAS No- 5980-31-4 | Simson Pharma Limited".
  4. "Γαληνός - Σκεύασμα - HEXALEN MOUTH.WASH 0,1% W/V FL x 200 ML (Γυάλινο φιαλίδιο) - Γενικά".
  5. (November 1991). "[The advantage of preventive vaginal antisepsis with hexetidine in obstetrics and gynecology]". Geburtshilfe Frauenheilkd.
  6. [http://medikamente.onmeda.de/Medikament/Vagi-Hex/med_gegenanzeigen-medikament-10.html Vagi-Hex: Gegenanzeigen] {{Webarchive. link. (2013-05-11 (Vagi-Hex: Counterindications, in German language))

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::

oral-hygienepyrimidinesdental-drugs